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  1. null (Ed.)
  2. Pb 2+ is a xenobiotic metal ion that competes for Ca 2+ -binding sites in proteins. Using the peripheral Ca 2+ -sensing domains of Syt1, we show that the chelating pH buffer Bis–Tris enables identification and functional characterization of high-affinity Pb 2+ sites that are likely to be targeted by bioavailable Pb 2+ . 
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